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A New Palladium‐Catalyzed Intramolecular Cyclization: Synthesis of 1‐Aminoindole Derivatives and Functionalization of their Carbocylic Rings
Author(s) -
Watanabe Makoto,
Yamamoto Toshihide,
Nishiyama Masakazu
Publication year - 2000
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20000717)39:14<2501::aid-anie2501>3.0.co;2-t
Subject(s) - surface modification , palladium , intramolecular force , catalysis , ring (chemistry) , chemistry , combinatorial chemistry , medicinal chemistry , organic chemistry , stereochemistry
Simultaneous cyclization and functionalization of the carbocylic ring of 1 (X=Cl) take place with amines, azoles, and phenylboronic acid in the presence of Pd catalysts to give 2 (R=amino, azolyl, Ph). Fluoro‐ and chloroindoles 2 (R=F, Cl) can be isolated in the absence of coupling agents. dba=dibenzylideneacetone.