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Halogen–Magnesium Exchange via Trialkylmagnesates for the Preparation of Aryl‐ and Alkenylmagnesium Reagents
Author(s) -
Kitagawa Kazuya,
Inoue Atsushi,
Shinokubo Hiroshi,
Oshima Koichiro
Publication year - 2000
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20000717)39:14<2481::aid-anie2481>3.0.co;2-j
Subject(s) - electrophile , aryl , halogen , reagent , magnesium , chemistry , halide , combinatorial chemistry , grignard reagent , metal , organic chemistry , catalysis , alkyl
Significantly better than simple Grignard reagents are the trialkylmagnesium‐ate complexes in the halogen–metal exchange reaction of aryl or alkenyl halides to the corresponding magnesates (see reaction scheme). The subsequent reaction of these ate complexes with electrophiles proceeds in good to excellent yields, and a number of functional groups (FG) can be tolerated.