Premium
Spectroscopic Evidence for a 4‐Methylidene Imidazol‐5‐one in Histidine and Phenylalanine Ammonia‐Lyases
Author(s) -
Röther Dagmar,
Merkel Dietrich,
Rétey János
Publication year - 2000
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20000717)39:14<2462::aid-anie2462>3.0.co;2-h
Subject(s) - histidine , electrophile , phenylalanine , ammonia , chemistry , enzyme , stereochemistry , biochemistry , catalysis , amino acid
HAL and PAL are closely related enzymes: They both contain a recently discovered highly electrophilic prosthetic group (shown in the picture) at the active site. This observation adds weight to the previously published hypothesis that the reactions catalyzed by HAL and PAL (histidine and phenylalanine ammonia‐lyases) have analogous mechanisms.