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Base‐Specific Minor Groove Site Binding in Metallo‐Nucleobase Polymers
Author(s) -
Shipman Michelle A.,
Price Clayton,
Elsegood Mark R. J.,
Clegg William,
Houlton Andrew
Publication year - 2000
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20000703)39:13<2360::aid-anie2360>3.0.co;2-6
Subject(s) - guanine , nucleobase , minor groove , chemistry , base pair , dna , cationic polymerization , groove (engineering) , base (topology) , stereochemistry , polymer chemistry , materials science , nucleotide , biochemistry , mathematical analysis , mathematics , gene , metallurgy
Polynucleobase strands , isolated from reactions of copper( II ) with diamine‐tethered derivatives of guanine and adenine, have been structurally characterized (see picture). These strands exhibit markedly different topologies resulting from a base‐specific minor groove site binding. The absence of this interaction for guanine generates a novel cationic polyguaninyl analogue.