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The Use of Immobilized Templates—A New Approach in Molecular Imprinting
Author(s) -
Yilmaz Ecevit,
Haupt Karsten,
Mosbach Klaus
Publication year - 2000
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20000616)39:12<2115::aid-anie2115>3.0.co;2-v
Subject(s) - template , theophylline , theobromine , polymer , molecular imprinting , monomer , molecularly imprinted polymer , polymerization , chemical engineering , molecule , dissolution , materials science , polymer chemistry , chemistry , combinatorial chemistry , porosity , nanotechnology , organic chemistry , catalysis , selectivity , biology , endocrinology , engineering
By using porous silica gel as a solid support , template molecules can be immobilized to give a novel approach to molecular imprinting in polymers. Polymerizable, functional monomers assemble around a template (such as theophylline, see picture). Following polymerization, this support is sacrificed by dissolving in HF. The remaining polymer shows a specific binding capacity for theophylline, but not for related compounds, such as theobromine and caffeine. All binding sites are uniformly oriented and located at the surface of the polymer.