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Preparation of Bioconjugates through an Ugi Reaction
Author(s) -
Ziegler Thomas,
Gerling Sonja,
Lang Martin
Publication year - 2000
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20000616)39:12<2109::aid-anie2109>3.0.co;2-9
Subject(s) - ugi reaction , combinatorial chemistry , conjugate , covalent bond , chemistry , organic chemistry , isocyanide , mathematics , mathematical analysis
Up to three reporter groups are covalently bound to a protein in one step by an Ugi reaction. Thus, protein conjugates can be prepared which bear up to three low molecular weight reporter groups in an equimolar ratio.