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Chiral 1,1′‐Diphosphetanylferrocenes: New Ligands for Asymmetric Catalytic Hydrogenation of Itaconate Derivatives
Author(s) -
Berens Ulrich,
Burk Mark J.,
Gerlach Arne,
Hems William
Publication year - 2000
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20000602)39:11<1981::aid-anie1981>3.0.co;2-3
Subject(s) - asymmetric hydrogenation , catalysis , combinatorial chemistry , noyori asymmetric hydrogenation , enantioselective synthesis , chemistry , stereochemistry , organic chemistry
The useful combination of high catalytic activity and high enantioselectivity is provided by rhodium catalysts based on a new class of FerroTANE ligands when employed in the hydrogenation of itaconate derivatives (see scheme). Reactions performed at S/C ratio of 20 000 are complete within 3 h and directly afford valuable 2‐alkylsuccinamide products in up to 99 % enantiomeric excess.