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Enantiopure Simple Analogues of Annonaceous Acetogenins with Remarkable Selective Cytotoxicity towards Tumor Cell Lines
Author(s) -
Zeng BuBing,
Wu Yikang,
Yu Qian,
Wu YuLin,
Li Yan,
Chen XiaoGuang
Publication year - 2000
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20000602)39:11<1934::aid-anie1934>3.0.co;2-w
Subject(s) - enantiopure drug , chemistry , cytotoxicity , stereochemistry , diastereomer , biological activity , combinatorial chemistry , biochemistry , in vitro , enantioselective synthesis , catalysis
Structure simplification with conservation of the essential functionalities for biological activity has been achieved with the design and synthesis of four analogues of annonaceous acetogenins. The compounds ((15 R / S , 24 R / S )‐ 1 ) are easily synthesized with L ‐ and/or D ‐glyceraldehyde acetonide and L ‐lactic acid as the chiral carbon sources. Preliminary biological tests of these compounds at cellular level show remarkable, selective antitumor activity.