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NMR Determination of Absolute Configuration of Butenolides of Annonaceous Type
Author(s) -
Latypov Shamil,
Franck Xavier,
Jullian JeanChristophe,
Hocquemiller Reynald,
Figadère Bruno
Publication year - 2002
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/1521-3765(20021216)8:24<5662::aid-chem5662>3.0.co;2-h
Subject(s) - butenolide , absolute configuration , diastereomer , chemistry , enantiomer , moiety , reagent , tetrahydrofuran , stereochemistry , organic chemistry , solvent
We report herein the first determination of the absolute configuration of the annonaceous butenolides by a NMR method. This technique uses a chiral solvating agent (CSA), the so‐called Pirkle's reagent, at low temperature and low concentration , allowing one to apply this method to other natural products as well. Indeed, the presence of basic sites (e.g. tetrahydrofuran, hydroxyl) did not interfere with the major solvation of the reagent with the lactone moiety. A new model is proposed which allowed us to confirm the ( S ) absolute configuration of the butenolide of annonaceous acetogenins. Furthermore this method can be successfully applied to the measure of the diastereomeric (or enantiomeric) excess of the same butenolide containing compounds.