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Covalently Bonded Platinum( II ) Complexes of α ‐Amino Acids and Peptides as a Potential Tool for Protein Labeling
Author(s) -
Guillena Gabriela,
Rodríguez Gema,
Albrecht Martin,
van Koten Gerard
Publication year - 2002
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/1521-3765(20021202)8:23<5368::aid-chem5368>3.0.co;2-d
Subject(s) - covalent bond , chemistry , amino acid , biomolecule , combinatorial chemistry , stereochemistry , organic chemistry , biochemistry
Arylplatinum (ii) complexes have been covalently bonded to the N and C termini and to the α ‐carbon of various amino acid derivatives. These organometallic‐functionalized amino acid compounds can be converted into the corresponding free amino acids under both basic and acidic conditions; this demonstrates the excellent stability properties of these biomolecules. Due to the NMR activity displayed by the 195 Pt nucleus (natural abundance 33.8 %, I =1/2) these compounds are functional biomarkers. Furthermore, the ability of the arylplatinum functional group to bind SO 2 gas, selectively and reversibly as indicated by changes in the spectroscopic properties ( 1 H, 13 C, 195 Pt NMR and UV spectra) of these compounds, allows for the potential use of these complexes as in vitro biosensors.