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Modeling of Prebiotic Catalysis with Adenylated Polymeric Templates: Crystal Structure Studies and Kinetic Characterization of Template‐Assisted Phosphate Ester Hydrolysis
Author(s) -
Srivatsan S. G.,
Parvez Masood,
Verma Sandeep
Publication year - 2002
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/1521-3765(20021115)8:22<5184::aid-chem5184>3.0.co;2-2
Subject(s) - chemistry , hydrolysis , catalysis , template , phosphate , nucleobase , monomer , combinatorial chemistry , prebiotic , organic chemistry , polymer chemistry , nanotechnology , polymer , materials science , dna , biochemistry
We have synthesized and characterized novel, copper‐metalated, polymeric templates that contain adenine nucleobases. These promote hydrolysis of non‐natural and natural phosphate ester substrates in a highly efficient and catalytic fashion. The crystal structure of the copper‐containing adenylated monomer reveals the formation of a polymeric array, through coordination to both N1 and N7 atoms. Possible implications of these studies for prebiotic catalysis, involving synergism between adenine and copper ions, are also discussed.