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Effect of Conformational Preorganization of a Three‐Armed Host on Anion Binding and Selectivity
Author(s) -
Hettche Frank,
Reiß Philipp,
Hoffmann Reinhard W.
Publication year - 2002
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/1521-3765(20021104)8:21<4946::aid-chem4946>3.0.co;2-v
Subject(s) - selectivity , chemistry , chloride , urea , receptor , ion , crystallography , stereochemistry , biophysics , biochemistry , organic chemistry , biology , catalysis
A set of three‐armed urea‐containing anion receptors was prepared. The receptors all have the same binding topology but differ in the level of conformational preorganisation with respect to the arrangement of the side‐arms relative to the platform and within the side arms themselves. This is mirrored in a specific increase (×2.5) in the binding constant for chloride and in a 12‐fold increase in the chloride/nitrate‐selectivity.