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Cover Picture: Chem. Eur. J. 20/2002
Author(s) -
Bando Toshikazu,
Narita Akihiko,
Saito Isao,
Sugiyama Hiroshi
Publication year - 2002
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/1521-3765(20021018)8:20<4565::aid-chem4565>3.0.co;2-b
Subject(s) - conjugate , moiety , imidazole , chemistry , cover (algebra) , ribbon , energy minimization , stereochemistry , crystallography , mathematics , computational chemistry , geometry , engineering , mechanical engineering , mathematical analysis
The cover picture shows the energy‐minimized structure of the dCAAGTCAGAG/dCTCTGACTTG pyrrole–imidazole (blue and red, respectively, hairpin CPI conjugate complex (CPI = cyclopropylpyrroloindole). Minimization was performed in the presence of 18 sodium cations and a 10 Å layer of H 2 O by CFF force‐field parameters. Each strand of DNA is drawn in white and ribbon representation is drawn in light blue. The CPI conjugate effectively alkylated the A moiety (purple) of 5′‐AGTC A ‐3′ site at nanomolar concentration. Further work is described in more detail by H. Sugiyama et al. on p. 4781 ff.