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Sequential Column Asymmetric Catalysis
Author(s) -
Hafez Ahmed M.,
Taggi Andrew E.,
Lectka Thomas
Publication year - 2002
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/1521-3765(20020916)8:18<4114::aid-chem4114>3.0.co;2-q
Subject(s) - column (typography) , reagent , catalysis , combinatorial chemistry , throughput , chemistry , solid phase synthesis , substrate (aquarium) , computer science , nanotechnology , materials science , organic chemistry , telecommunications , peptide , biochemistry , oceanography , geology , frame (networking) , wireless
Since the introduction of catalysts and reagents on solid‐support, researchers have developed new reaction systems to take advantage of their insoluble nature by designing multistep reaction sequences, high‐throughput purification techniques, and combinatorial synthesis methods. The continuous flow system is one of these advancements and represents the foundation of a new technique termed sequential column asymmetric catalysis (CAC). In this strategy, reagents and catalysts are attached to a solid‐phase support and loaded onto sequentially‐linked columns. The substrates are present in the liquid phase that flows through the column. As a substrate encounters each successive column, it grows in complexity. Consequently, one can imagine a number of flow systems that consist of columns attached in series and/or in parallel that synthesize a fairly complex molecule. Herein, we discuss the development of the sequential CAC technique, beginning with the most relevant antecedents.