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Transition‐Metal‐Catalyzed Carbon–Heteroatom Three‐Component Cross‐Coupling Reactions: A New Concept for Carbothiolation of Alkynes
Author(s) -
Kuniyasu Hitoshi,
Kurosawa Hideo
Publication year - 2002
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/1521-3765(20020617)8:12<2660::aid-chem2660>3.0.co;2-q
Subject(s) - alkyne , catalysis , heteroatom , transition metal , coupling reaction , ligand (biochemistry) , chemistry , reductive elimination , coupling (piping) , polymer chemistry , carbon fibers , metal , combinatorial chemistry , materials science , organic chemistry , ring (chemistry) , biochemistry , receptor , composite number , metallurgy , composite material
The deep‐seated understanding of flexible ligand behavior of thiolate on transition‐metals has paved the way to achieve metal‐catalyzed carbothiolations of terminal alkynes. The strategy of the reaction is quite simple: 1) generation of the complex with CPtS fragments formed after the Pd‐catalyzed CS bond‐forming cross‐coupling reaction, 2) insertion of an alkyne into PtS bond to form the complex with a CPtC fragment, and 3) CC bond‐forming reductive elimination.