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Analytical Construct Resins for Analysis of Solid‐Phase Chemistry
Author(s) -
Congreve Miles S.,
Ley Steven V.,
Scicinski Jan J.
Publication year - 2002
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/1521-3765(20020415)8:8<1768::aid-chem1768>3.0.co;2-j
Subject(s) - linker , cleavage (geology) , solid phase synthesis , chemistry , polymer , combinatorial chemistry , phase (matter) , computer science , materials science , organic chemistry , composite material , peptide , biochemistry , fracture (geology) , operating system
Rapid and unambiguous analysis of reactions performed on resin supports can be achieved by using “analytical constructs”. These resins allow the synthesis of materials using solid‐phase methods in the usual manner, but they also contain functionality enabling cleavage of analytically enhanced derivatives of the resin‐bound products. This is possible due to the use of two linkers bound in series to the polymer. Cleavage at the first linker yields the products attached to an analytical enhancer that facilitates detection. Orthogonal cleavage at the second linker yields the desired products in the usual manner.