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Crystallization‐Induced Diastereoselection: Asymmetric Synthesis of Substance P Inhibitors
Author(s) -
Pye Philip J.,
Rossen Kai,
Weissman Steven A.,
Maliakal Ashok,
Reamer Robert A.,
Ball Richard,
Tsou Nancy N.,
Volante R. P.,
Reider Paul J.
Publication year - 2002
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/1521-3765(20020315)8:6<1372::aid-chem1372>3.0.co;2-6
Subject(s) - crystallization , condensation , transformation (genetics) , sequence (biology) , combinatorial chemistry , chemistry , stereochemistry , biochemistry , organic chemistry , gene , physics , thermodynamics
A novel three‐component condensation followed by a crystallization‐induced asymmetric transformation is used to build this key substance P inhibitor intermediate in a short synthetic sequence.