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Cover Picture: Chem. Eur. J. 6/2002
Author(s) -
Pye Philip J.,
Rossen Kai,
Weissman Steven A.,
Maliakal Ashok,
Reamer Robert A.,
Ball Richard,
Tsou Nancy N.,
Volante R. P.,
Reider Paul J.
Publication year - 2002
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/1521-3765(20020315)8:6<1249::aid-chem1249>3.0.co;2-d
Subject(s) - glyoxal , chemistry , crystallization , crystallography , aryl , stereochemistry , single crystal , organic chemistry , alkyl
The cover picture shows the structures of the complex mixture of isomers obtained from a three‐component cyclization of an aryl boronic acid with glyoxal and an aminodiol (left). Crystallization, induced by seeding the mixture, resulted in the transformation of these isomers to the single cis isomer as shown on the right. The background depicts the crystal packing of this cis ‐lactol as determined by single‐crystal X‐ray analysis. The compounds are key intermediates for the synthesis of the Merck substance P inhibitors. This work is described in more detail by P. J. Pye and K. Rossen et al. on p. 1372 ff.