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Sulfide Oxidation by Hydrogen Peroxide Catalyzed by Iron Complexes: Two Metal Centers Are Better Than One
Author(s) -
Mekmouche Yasmina,
Hummel Helga,
Ho Raymond Y. N.,
Que, Jr. Lawrence,
Schünemann Volker,
Thomas Fabrice,
Trautwein Alfred X.,
Lebrun Colette,
Gorgy Karine,
Leprêtre JeanClaude,
Collomb MarieNoëlle,
Deronzier Alain,
Fontecave Marc,
Ménage Stéphane
Publication year - 2002
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/1521-3765(20020301)8:5<1196::aid-chem1196>3.0.co;2-z
Subject(s) - catalysis , hydrogen peroxide , chemistry , enantioselective synthesis , sulfide , stereoselectivity , adduct , metal , combinatorial chemistry , peroxide , medicinal chemistry , organic chemistry
Peroxoiron species have been proposed to be involved in catalytic cycles of iron‐dependent oxygenases and in some cases as the active intermediates during oxygen‐transfer reactions. The catalytic properties of a mononuclear iron complex, [Fe II (pb) 2 (CH 3 CN) 2 ] (pb=(−)4,5‐pinene‐2,2′‐bipyridine), have been compared to those of its related dinuclear analogue. Each system generates specific peroxo adducts, which are responsible for the oxidation of sulfides to sulfoxides. The dinuclear catalyst was found to be more reactive and (enantio)selective than its mononuclear counterpart, suggesting that a second metal site affords specific advantages for stereoselective catalysis. These results might help for the design of future enantioselective iron catalysts.