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How To Synthesize Macrocycles Efficiently by Using Virtual Combinatorial Libraries
Author(s) -
Storm Ole,
Lüning Ulrich
Publication year - 2002
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/1521-3765(20020215)8:4<793::aid-chem793>3.0.co;2-u
Subject(s) - scope (computer science) , ion , alkaline earth metal , combinatorial chemistry , molecule , chemistry , selection (genetic algorithm) , computer science , materials science , alkali metal , organic chemistry , programming language , artificial intelligence
The selection of different diimines 4 a – c by alkaline earth ions from a virtual combinatorial library (VCL) is described. The products were stabilized by reduction to the diamines 6 a – c ; this allowed easy analysis. The library can be directed toward different target molecules 6 a – c upon addition of alkaline earth ions with different radii. Competition experiments show the possibility of synthesizing the macrocycles 6 a, 6 b , and 6 c simultaneously when using Mg 2+ , Ca 2+ , and Ba 2+ as template ions. The scope of this thermodynamically controlled, reversible approach for macrocycle syntheses is illustrated.