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Development of Dirhodium( II )‐Catalyzed Generation and Enantioselective 1,3‐Dipolar Cycloaddition of Carbonyl Ylides
Author(s) -
Hodgson David M.,
Stupple Paul A.,
Pierard Françoise Y. T. M.,
Labande Agnès H.,
Johnstone Craig
Publication year - 2001
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/1521-3765(20011015)7:20<4465::aid-chem4465>3.0.co;2-w
Subject(s) - enantioselective synthesis , cycloaddition , ylide , catalysis , diazo , chemistry , tandem , 1,3 dipolar cycloaddition , azomethine ylide , medicinal chemistry , organic chemistry , materials science , composite material
Catalytic, enantioselective, tandem carbonyl ylide formation/cycloaddition of 2‐diazo‐3,6‐diketoester 2 with the use of dirhodium tetrakiscarboxylate and tetrakisbinaphtholphosphate catalysts to give the cycloadducts 3 in good yields and up to 90 % ee is described.