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The Persistent Radical Effect in Organic Synthesis
Author(s) -
Studer Armido
Publication year - 2001
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/1521-3765(20010316)7:6<1159::aid-chem1159>3.0.co;2-i
Subject(s) - nitroxide mediated radical polymerization , chemistry , radical cyclization , coupling reaction , organic synthesis , cobalt mediated radical polymerization , radical ion , radical , free radical reaction , photochemistry , catalysis , combinatorial chemistry , organic chemistry , radical polymerization , ion , copolymer , polymer
The persistent radical effect (PRE) is a principle that explains the highly selective cross‐coupling between a persistent and a transient radical when both species are formed at equal rates. In this paper, the concept of the PRE is briefly discussed. Applications of the PRE in different reactions such as Co‐mediated radical addition and cyclization reactions, Kharasch reactions catalyzed by transition metals, the Barton reaction, and our nitroxide‐mediated tin‐free radical cyclizations are presented. Some future perspectives for the PRE in organic synthesis are also provided.