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Development of an Easy‐to‐Use Mass Spectrometric Technique to Monitor Solid‐Phase Reactions on Polystyrene Supports
Author(s) -
Heinze Katja,
Winterhalter Ute,
Jannack Thomas
Publication year - 2000
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/1521-3765(20001117)6:22<4203::aid-chem4203>3.0.co;2-q
Subject(s) - polystyrene , mass spectrometry , mass spectrum , polymer , chemistry , solid phase synthesis , molecule , cleavage (geology) , phase (matter) , analytical chemistry (journal) , chromatography , materials science , organic chemistry , peptide , biochemistry , fracture (geology) , composite material
By using mass spectrometry as an analytical tool to characterise substituted, cross‐linked polystyrene resins, it is possible to directly monitor the progress of the solid‐phase reactions performed on these resins without prior cleavage of the resin‐bound molecules. Therefore, this is a true on‐resin analytical method. The mass‐to‐charge ratios observed in the mass spectra are readily assigned to fragments of the polymer that include the chemically bound substituents. This is the first time that the formation and breaking of bonds have been directly observed on the polymeric support. Furthermore, the relative intensities of the signals in the mass spectra provide a measure of the completeness of the reaction. Because these measurements are rapidly performed without further chemical transformations or cleavage procedures, and because only minimal amounts of material are needed, this technique could become the solid‐phase equivalent of thin‐layer chromatography used in classical liquid‐phase chemistry.