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Traceless Linkers‐Only Disappearing Links in Solid‐Phase Organic Synthesis?
Author(s) -
Bräse Stefan,
Dahmen Stefan
Publication year - 2000
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/1521-3765(20000602)6:11<1899::aid-chem1899>3.0.co;2-m
Subject(s) - heteroatom , solid phase synthesis , group (periodic table) , combinatorial chemistry , polymer , molecule , organic molecules , chemistry , phase (matter) , nanotechnology , materials science , polymer chemistry , organic chemistry , ring (chemistry) , biochemistry , peptide
Traceless linkers, which enable the attachment of arenes and alkanes to a polymeric support, have received increased attention in recent years. These anchoring groups allow chemical transformations on the polymer‐bound molecules, which can be cleaved from the resin leaving no residual functionality to bias the library. Various approaches based on different Group 14 to Group 16 heteroatoms have been developed in the past and used in new syntheses of diverse compound libraries.