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Activation of STAT proteins and growth control
Author(s) -
Bromberg Jacqueline F.
Publication year - 2001
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/1521-1878(200102)23:2<161::aid-bies1023>3.0.co;2-0
Subject(s) - stat , stat4 , transcription factor , microbiology and biotechnology , stat protein , signal transduction , stat6 , biology , transcription (linguistics) , cancer research , gene , genetics , stat3 , linguistics , philosophy
This review will discuss how STAT ( S ignal T ransducers and A ctivators of T ranscription) proteins, a group of transcription factors that transmit signals from the extracellular surface of cells to the nucleus, are involved in growth control. I will discuss the anatomy of a STAT protein, how it works as a transcription factor, the molecules that regulate its “activity”, the phenotypes of mice that lack individual STAT proteins and their involvement in growth, differentiation, apoptosis, and transformation. Finally, a number of examples will be presented of how dysregulated STAT signaling may be involved in the pathogenesis of cancer. BioEssays 23:161–169, 2001. © 2001 John Wiley & Sons, Inc.