Premium
The puzzling multiple lives of PML and its role in the genesis of cancer
Author(s) -
Ruggero Davide,
Wang ZhuGang,
Pandolfi Pier Paolo
Publication year - 2000
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/1521-1878(200009)22:9<827::aid-bies8>3.0.co;2-1
Subject(s) - promyelocytic leukemia protein , suppressor , biology , transcription factor , nuclear protein , transcription (linguistics) , mediator , leukemia , function (biology) , microbiology and biotechnology , cancer research , gene , genetics , philosophy , linguistics
PML , the gene associated with acute promyelocytic leukemia (APL); PML, the target of numerous viral agents; PML, the growth suppressor; PML, the mediator of multiple apoptotic pathways; PML, the tumor suppressor; PML, the protein which epitomizes a novel nuclear structure, the nuclear body; PML, the transcription co‐factor. Despite the recent flurry of reports attributing multiple biological roles to the PML protein, PML still lacks a definitive biochemical function. This is probably the reason why PML is so attractive to many investigators. Here, we will summarize the facts and speculations on this puzzling protein. BioEssays 22:827–835, 2000. © 2000 John Wiley & Sons, Inc.