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Integrating the MAP kinase signal into the G1 phase cell cycle machinery
Author(s) -
Roovers Kristin,
Assoian Richard K.
Publication year - 2000
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/1521-1878(200009)22:9<818::aid-bies7>3.0.co;2-6
Subject(s) - mapk/erk pathway , microbiology and biotechnology , receptor tyrosine kinase , mitogen activated protein kinase , signal transduction , kinase , integrin , biology , cell cycle , tyrosine kinase , integrin linked kinase , mapk cascade , chemistry , protein kinase a , cell , biochemistry , cyclin dependent kinase 2
Growth factors and the extracellular matrix provide the environmental cues that control the proliferation of most cell types. The binding of growth factors and matrix proteins to receptor tyrosine kinases and integrins, respectively, regulates several cytoplasmic signal transduction cascades, among which activation of the mitogen‐activated protein kinase cascade, ras → Raf → MEK → ERK, is perhaps the best characterized. Curiously, ERK activation has been associated with both stimulation and inhibition of cell proliferation. In this review, we summarize recent studies that connect ERK signaling to G1 phase cell cycle control and suggest that the cellular response to an ERK signal depends on both ERK signal intensity and duration. We also discuss studies showing that receptor tyrosine kinases and integrins differentially regulate the ERK signal in G1 phase. BioEssays 22:818–826, 2000. © 2000 John Wiley & Sons, Inc.