Premium
Environmental signals and cell fate specification in premigratory neural crest
Author(s) -
Dorsky Richard I.,
Moon Randall T.,
Raible David W.
Publication year - 2000
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/1521-1878(200008)22:8<708::aid-bies4>3.0.co;2-n
Subject(s) - neural crest , biology , embryonic stem cell , cranial neural crest , crest , cell fate determination , microbiology and biotechnology , population , neuroscience , genetics , gene , embryo , physics , demography , quantum mechanics , sociology , transcription factor
Neural crest cells are multipotent progenitors, capable of producing diverse cell types upon differentiation. Recent studies have identified significant heterogeneity in both the fates produced and genes expressed by different premigratory crest cells. While these cells may be specified toward particular fates prior to migration, transplant studies show that some may still be capable of respecification at this time. Here we summarize evidence that extracellular signals in the local environment may act to specify premigratory crest and thus generate diversity in the population. Three main classes of signals–Wnts, BMP2/BMP4 and TGFβ1,2,3–have been shown to directly influence the production of particular neural crest cell fates, and all are expressed near the premigratory crest. This system may therefore provide a good model for integration of multiple signaling pathways during embryonic cell fate specification. BioEssays 22:708–716, 2000. © 2000 John Wiley & Sons, Inc.