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Cell death: a trigger of autoimmunity?
Author(s) -
Rodenburg R.J.T.,
Raats J.M.H.,
Pruijn G.J.M.,
van Venrooij W.J.
Publication year - 2000
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/1521-1878(200007)22:7<627::aid-bies5>3.0.co;2-k
Subject(s) - autoimmunity , immunology , immune system , antibody , biology , programmed cell death , antigen , genetics , apoptosis
Systemic autoimmune diseases are characterized by the production of antibodies against a broad range of self‐antigens. Recent evidence indicates that the majority of these autoantigens are modified in various ways during cell death. This has led to the hypothesis that the primary immune response in the development of autoimmunity is directed to components of the dying cell. In this article, we summarize data on the modification of autoantigens during cell death and the possible consequences of this for autoimmunity. BioEssays 22:627–636, 2000. © 2000 John Wiley & Sons, Inc.