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A magnetic field exposure facility for evaluation of animal carcinogenicity
Author(s) -
Maruvada P.S.,
Harvey S.M.,
Jutras P.,
Goulet D.,
Mandeville R.
Publication year - 2000
Publication title -
bioelectromagnetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.435
H-Index - 81
eISSN - 1521-186X
pISSN - 0197-8462
DOI - 10.1002/1521-186x(200009)21:6<432::aid-bem3>3.0.co;2-x
Subject(s) - bioelectromagnetics , occupational exposure , magnetic field , quality assurance , calibration , nuclear medicine , medicine , biomedical engineering , physics , veterinary medicine , pathology , statistics , mathematics , environmental health , external quality assessment , quantum mechanics
Several animal studies have been carried out at the Institut Armand Frappier (IAF) to determine whether chronic exposure to 60 Hz linearly polarized sinusoidal magnetic fields might increase the risk of cancer development of female Fisher rats. The magnetic field exposure facility was developed to meet the requirements of the study protocol for chronic exposure of large number of animals to field intensities of sham < 0.2 μT, 2 μT, 20 μT, 200 μT, and 2000 μT. At each exposure level, including sham, the animals are distributed in a group of four exposure units. Each exposure unit contains two exposure volumes having uniform distribution of magnetic fields for the animals, while the magnetic field external to the unit falls off rapidly due to the “figure‐eight” coil topography used. A program of “shake down” tests, followed by verification and calibration of the exposure facility, was carried out prior to starting the animal experiments. Continuous monitoring of the magnetic field and other environmental parameters was an important part in the overall quality assurance program adopted. Bioelectromagnetics 21:432–438, 2000. © 2000 Wiley‐Liss, Inc.