Premium
Insulin resistance, cardiovascular risk factors and ultrasonically measured early arterial disease in normotensive Type 2 diabetic subjects
Author(s) -
Kong C.,
Elatrozy T.,
Anyaoku V.,
Robinson S.,
Richmond W.,
Elkeles R. S.
Publication year - 2000
Publication title -
diabetes/metabolism research and reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.307
H-Index - 110
eISSN - 1520-7560
pISSN - 1520-7552
DOI - 10.1002/1520-7560(2000)9999:9999<::aid-dmrr154>3.0.co;2-n
Subject(s) - medicine , insulin resistance , insulin , endocrinology , body mass index , asymptomatic , triglyceride , intima media thickness , diabetes mellitus , high density lipoprotein , cholesterol , carotid arteries
Background The objective of the study was to examine the relationship between serum fasting insulin, insulin sensitivity S i , cardiovascular risk factors, and asymptomatic early atherosclerosis in normotensive Type 2 diabetic subjects. Methods Specific insulin was measured using an enzyme‐linked immunosorbent assay (ELISA) and insulin sensitivity was assessed with an insulin‐modified frequently sampled intravenous glucose tolerance test (FSIVGTT). Early atherosclerotic change was assessed using carotid intima media thickness (IMT) and an arterial ultrasound score (AUS) measured by high‐resolution B‐mode ultrasound. Results On bivariate analysis, there was a positive correlation between S i and high density lipoprotein (HDL) cholesterol ( r s =0.27, p <0.05), and a negative correlation between S i and body mass index (BMI) ( r s =−0.42, p <0.001), HbA 1c ( r s =−0.29, p <0.05) and serum triglyceride ( r s =−0.30, p <0.05). There was a positive correlation between carotid IMT and age ( r s =0.41, p <0.0005), and a positive association with male sex ( p <0.0001) as well as with smoking ( p <0.0001). However, we found no correlation between carotid IMT and fasting specific insulin ( r s =−0.04) or S i ( r s =−0.08). On multiple regression analyses, only age and serum triglycerides appeared to be significant independent variables with respect to carotid IMT whereas age, male sex and smoking emerged jointly significant with respect to AUS. There were no independent associations between carotid IMT or AUS with other variables including using either fasting specific insulin or S i as markers on insulin resistance separately. Conclusion Carotid IMT and AUS in Type 2 diabetes are closely associated with age, male sex and smoking. The relationships between serum insulin and insulin resistance with ultrasonically measured early arterial disease in Type 2 diabetes remain unclear. Copyright © 2000 John Wiley & Sons, Ltd.