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Non‐specific viral infections as possible synchronising events of the manifestation of Type 1 diabetes
Author(s) -
Wasmuth Hermann E.,
Hess Gregor,
Viergutz Christoph,
Henrichs Helmut R.,
Martin Stephan,
Kolb Hubert
Publication year - 2000
Publication title -
diabetes/metabolism research and reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.307
H-Index - 110
eISSN - 1520-7560
pISSN - 1520-7552
DOI - 10.1002/1520-7560(0000)9999:9999<::aid-dmrr100>3.0.co;2-5
Subject(s) - diabetes mellitus , insulin , insulin resistance , medicine , type 2 diabetes , type 1 diabetes , dependency (uml) , virology , immunology , endocrinology , computer science , software engineering
Four cases of simultaneous manifestation of Type 1 diabetes in two members of the same household are reported. In all cases, a flu‐like infection preceded diabetes onset. Surprisingly, despite simultaneous development of insulin dependency, insulin requirements were strikingly different at 3 months in all cases. These observations suggest that increased insulin resistance during infection may cause insulin deficiency in individuals with widely varying residual β cell activity. Copyright © 2000 John Wiley & Sons, Ltd.