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Effect of methoxamine on maximum urethral pressure in women with genuine stress incontinence: A placebo‐controlled, double‐blind crossover study
Author(s) -
Radley S.C.,
Chapple C.R.,
Bryan N.P.,
Clarke D.E.,
Craig D.A.
Publication year - 2000
Publication title -
neurourology and urodynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 90
eISSN - 1520-6777
pISSN - 0733-2467
DOI - 10.1002/1520-6777(2001)20:1<43::aid-nau6>3.0.co;2-f
Subject(s) - medicine , crossover study , placebo , methoxamine , double blind , stress incontinence , urinary incontinence , urology , anesthesia , agonist , alternative medicine , receptor , pathology
The aim of the study was to evaluate the potential role for a selective α 1 ‐adrenoceptor agonist in the treatment of urinary stress incontinence. A randomised, double‐blind, placebo‐controlled, crossover study design was employed. Half log incremental doses of intravenous methoxamine or placebo (saline) were administered to a group of women with genuine stress incontinence while measuring maximum urethral pressure (MUP), blood pressure, heart rate, and symptomatic side effects. Methoxamine evoked non‐significant increases in MUP and diastolic blood pressure but caused a significant rise in systolic blood pressure and significant fall in heart rate at maximum dosage. Systemic side effects including piloerection, headache, and cold extremities were experienced in all subjects. The results indicate that the clinical usefulness of direct, peripherally acting sub‐type‐selective α 1 ‐adrenoceptor agonists in the medical treatment of stress incontinence may be limited by associated piloerection and cardiovascular side effects. Neurourol. Urodynam. 20:43–52, 2001. © 2001 Wiley‐Liss, Inc.