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Enantioselectivity of 3‐amino‐2‐oxazolidinone derivatives with potential psychotropic activity on cellulose tris(4‐methylbenzoate) chiral selector
Author(s) -
Chilmonczyk Zdzisław,
Ksycińska Hanna,
Krzywda Jerzy,
IskraJopa Joanna
Publication year - 2001
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/1520-636x(2001)13:3<148::aid-chir1012>3.0.co;2-y
Subject(s) - chemistry , tris , enantiomer , stereochemistry , chirality (physics) , combinatorial chemistry , biochemistry , chiral symmetry , physics , quantum mechanics , nambu–jona lasinio model , quark
The behavior of a series of 3‐amino‐2‐oxazolidinone derivatives with a potential hypnotic activity on achiral (octadecylsilane) and chiral (cellulose tris(4‐methylbenzoate)) stationary phases was examined. The compounds differed in the composition of a substituted aromatic ring containing different substituents in different positions. It was possible to resolve all the compounds with selectivity 1.11 ≤ α ≤ 2.74. The enantiodifferentiating power of substituents was correlated to their electron donating ability and position in the aromatic ring. Chirality 13:148–152, 2001. © Wiley‐Liss, Inc.