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Cover Picture: ChemPhysChem 5/2002
Author(s) -
Hess Stephan,
Davis William B.,
Voityuk Alexander A.,
Rösch Notker,
MichelBeyerle Maria E.,
Ernsting Nikolaus P.,
Kovalenko Sergeij A.,
Pérez Lustres J. Luis
Publication year - 2002
Publication title -
chemphyschem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.016
H-Index - 140
eISSN - 1439-7641
pISSN - 1439-4235
DOI - 10.1002/1439-7641(20020517)3:5<385::aid-cphc385>3.0.co;2-0
Subject(s) - chromophore , nucleobase , chemistry , guanine , dna , stacking , relaxation (psychology) , excited state , acridine , nanosecond , solvation , photochemistry , chemical physics , molecule , nucleotide , social psychology , biochemistry , psychology , physics , laser , organic chemistry , nuclear physics , optics , gene
The cover picture shows an acridine derivative (ACMA) intercalated at an abasic site between nucleobases in B‐DNA. Unlike the Stokes shift on the nanosecond time scale reported for this chromophore in polar solvents, dynamic solvation of 1 (ACMA)* in DNA occurs within 200 fs. The absence of slow relaxation components has been shown to be important for the mechanism of the photoinduced oxidation of distant guanine molecules. Besides this mechanistic issue, excited‐state dynamics of chromophores bound to DNA are most relevant for their application in sequencing and genomic chip technologies.