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Redox Targeting of Oligonucleotides Anchored to Nanocrystalline TiO 2 Films for DNA Detection
Author(s) -
Meier KarlRichard,
Grätzel Michael
Publication year - 2002
Publication title -
chemphyschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.016
H-Index - 140
eISSN - 1439-7641
pISSN - 1439-4235
DOI - 10.1002/1439-7641(20020415)3:4<371::aid-cphc371>3.0.co;2-o
Subject(s) - oligonucleotide , nanocrystalline material , guanine , redox , dna , ruthenium , chemistry , anatase , nanotechnology , materials science , mesoporous material , combinatorial chemistry , inorganic chemistry , catalysis , biochemistry , nucleotide , photocatalysis , gene
DNA immobilization on mesoporous nanocrystalline anatase films produces a striking enhancement of the oxidation current, which is a result of targeting guanine by a ruthenium‐based redox mediator. The amperometric response can be used to monitor hybridization, rendering this system attractive for DNA chips.