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23 Na NMR Relaxation Studies of the Na‐DNA/Drug Interaction
Author(s) -
Cesare Marincola Flaminia,
Casu Mariano,
Saba Giuseppe,
Lai Adolfo
Publication year - 2001
Publication title -
chemphyschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.016
H-Index - 140
eISSN - 1439-7641
pISSN - 1439-4235
DOI - 10.1002/1439-7641(20011015)2:10<569::aid-cphc569>3.0.co;2-s
Subject(s) - relaxation (psychology) , chemistry , transverse relaxation optimized spectroscopy , counterion , nuclear magnetic resonance spectroscopy , dna , chemical physics , molecule , nuclear magnetic resonance , fluorine 19 nmr , computational chemistry , analytical chemistry (journal) , ion , stereochemistry , chromatography , organic chemistry , physics , biochemistry , psychology , social psychology
This Minireview covers the methodological approaches of 23 Na NMR spectroscopy to the study of the structure and dynamics of the DNA molecule, in particular the application of the 23 Na NMR quadrupolar relaxation to investigate the perturbations on the polyion surface due to exogenous agents. A brief description of the 23 Na NMR quadrupolar relaxation and of the models used to describe the distribution of counterions around DNA, and the results of the application of the 23 Na NMR relaxation to the study of the cation–DNA interaction are also shown. Following sections present results of the investigation on ligand–DNA interaction and on ordered DNA systems.