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Binding of Organic Anions by Synthetic Supramolecular Metallopores with Internal Mg 2+ –Aspartate Complexes
Author(s) -
Das Gopal,
Onouchi Hisanari,
Yashima Eiji,
Sakai Naomi,
Matile Stefan
Publication year - 2002
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/1439-7633(20021104)3:11<1089::aid-cbic1089>3.0.co;2-v
Subject(s) - chemistry , supramolecular chemistry , transmembrane protein , lipid bilayer , adenosine triphosphate , bilayer , membrane , barrel (horology) , biophysics , stereochemistry , crystallography , combinatorial chemistry , biochemistry , crystal structure , materials science , composite material , receptor , biology
We report that cation‐selective transmembrane pores formed by synthetic p ‐octiphenyl β barrels with internal aspartate residues can be transformed into anion‐permeable metallopores with internal Mg 2+ –aspartate complexes. These metallopores are shown to be useful for fluorimetric sensing of a broad variety of organic anions of biological relevance such as phytate, heparin, thiamine phosphates, and adenosine triphosphate. The negligible flippase activity measurable for Mg 2+ ‐free pores indicates that transmembrane p ‐octiphenyl β barrels do not disturb the lipid bilayer suprastructure, in other words, they form barrel–stave rather than toroidal pores.