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Synthesis and Biological Investigation of Novel Tricyclic Benzodiazepinedione‐Based RGD Analogues
Author(s) -
Addicks Elisabeth,
Mazitschek Ralph,
Giannis Athanassios
Publication year - 2002
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/1439-7633(20021104)3:11<1078::aid-cbic1078>3.0.co;2-2
Subject(s) - integrin , cell adhesion , extracellular matrix , tricyclic , chemistry , adhesion , microbiology and biotechnology , cell adhesion molecule , cell , affinities , receptor , biochemistry , stereochemistry , biology , organic chemistry
Abstract Integrins, a widely expressed family of heterodimeric cell surface adhesion proteins, are expressed in a variety of cell types. They play a decisive role in cell–cell adhesion or cell to extracellular matrix adhesion events. Antagonists of α v β 3 or α IIb β 3 integrin may have a potential use in suppression of pathological processes. We present the synthesis of novel tricyclic benzodiazepinedione‐based RGD analogues, which were subsequently tested in a solid‐phase receptor assay in order to investigate their binding affinities towards α v β 3 and α IIb β 3 integrin.