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Cover Picture: ChemBioChem 11/2002
Author(s) -
Das Gopal,
Onouchi Hisanari,
Yashima Eiji,
Sakai Naomi,
Matile Stefan
Publication year - 2002
Publication title -
chembiochem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/1439-7633(20021104)3:11<1033::aid-cbic1033>3.0.co;2-3
Subject(s) - barrel (horology) , chemistry , supramolecular chemistry , pyrophosphate , lipid bilayer , crystallography , bilayer , stereochemistry , combinatorial chemistry , biophysics , membrane , biochemistry , materials science , enzyme , crystal structure , biology , composite material
The cover picture shows a synthetic barrel‐stave pore in action. The pore, constructed from rigid‐rod ”staves” and β‐sheet ”hoops” (purple), has a hydrophobic exterior to interact with the surrounding lipid bilayer (L, blue) and internal aspartates (D) to interact with hydrophilic guests passing through. This supramolecular barrel can be "filled". Binding of magnesium cations (yellow) within the rigid‐rod β barrel produces an anion‐permeable metallopore (left). Subsequent binding of various organic anions (green) makes the barrel full (middle). Metallopore inactivation by internal anion binding allows heparin, adenosine triphosphate, phytate, thiamine pyrophosphate, and so on to be seen with the naked eye. Further details can be found in the article by Matile and co‐workers on p. 1089 ff.