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Dynamics in Rhodopsin
Author(s) -
KleinSeetharaman Judith
Publication year - 2002
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/1439-7633(20021004)3:10<981::aid-cbic981>3.0.co;2-9
Subject(s) - rhodopsin , biophysics , conformational change , chemistry , mutagenesis , g protein coupled receptor , signal transduction , cysteine , biology , biochemistry , mutation , retinal , gene , enzyme
Dancing in the dark : Much is known about the structure and light‐induced conformational changes of the mammalian dim‐light receptor rhodopsin, a model system for the entire G‐protein‐coupled receptor family. Less attention has been paid to the dynamic properties of rhodopsin. Growing evidence for the presence of large backbone motions in the inactive dark‐state conformation of rhodopsin and their importance for the functional, light‐induced conformational changes necessary for signal transduction are reviewed here. Cysteine mutagenesis experiments and spectroscopic techniques are combined to reveal more information about the protein dynamics.