Premium
Purine‐Based Inhibitors of Inositol‐1,4,5‐trisphosphate‐3‐kinase
Author(s) -
Chang YoungTae,
Choi Gildon,
Bae YoeSik,
Burdett Matthew,
Moon HoSang,
Lee Jae Wook,
Gray Nathanael S.,
Schultz Peter G.,
Meijer Laurent,
Chung SungKee,
Choi Kwan Yong,
Suh PannGhill,
Ryu Sung Ho
Publication year - 2002
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/1439-7633(20020902)3:9<897::aid-cbic897>3.0.co;2-b
Subject(s) - inositol , chemistry , purine , inositol phosphate , kinase , biochemistry , phosphatase , calcium , phospholipase c , enzyme , receptor , organic chemistry
Calcium metabolism regulation may be studied by use of a novel purine‐based inhibitor of inositol 1,4,5‐trisphosphate 3‐kinase (IP3K) developed by purine library screening (IC 50 =10.2 μ M ). This new IP3K inhibitor 1 increased Ca 2+ ion release as a result of IP3 accumulation in HL60 cells but did not affect any other metabolic enzymes, such as inositol 1,4,5‐trisphosphate 5‐phosphatase or phospholipase C.