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G‐Protein Subunit Dissociation Is not an Integral Part of G‐Protein Action
Author(s) -
Levitzki Alexander,
Klein Shoshana
Publication year - 2002
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/1439-7633(20020902)3:9<815::aid-cbic815>3.0.co;2-e
Subject(s) - protein subunit , chemistry , dissociation (chemistry) , stereochemistry , biophysics , biochemistry , biology , organic chemistry , gene
Challenging the dogma: The textbook model for activation of heterotrimeric G proteins is reexamined in this minireview. Subunit dissociation has only been demonstrated directly for transducin. Other G proteins may remain closely associated in multiprotein complexes, with activation involving a conformational change.