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Cover Picture: ChemBioChem 7/2002
Author(s) -
Dal Piaz Fabrizio,
Casapullo Agostino,
Randazzo Antonio,
Riccio Raffaele,
Pucci Piero,
Marino Gennaro,
GomezPaloma Luigi
Publication year - 2002
Publication title -
chembiochem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/1439-7633(20020703)3:7<587::aid-cbic587>3.0.co;2-u
Subject(s) - cover (algebra) , stereochemistry , natural product , chemistry , active site , ring (chemistry) , enzyme , molecule , combinatorial chemistry , biochemistry , organic chemistry , engineering , mechanical engineering
The cover picture shows the petrosaspongiolide M molecule (PM), a marine natural product with potent anti‐inflammatory activity, docked into the active site of phospholipase A 2 (PLA 2 ). The pharmacophoric γ ‐hydroxybutenolide ring of PM lies in close proximity to the N terminus of the enzyme. Further details can be found in the article by Gomez Paloma and co‐workers on p 664 ff.