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Synthesis and NMR Structure of Peptidomimetic α4β7‐Integrin Antagonists
Author(s) -
Gottschling Dirk,
Boer Jürgen,
Marinelli Luciana,
Voll Georg,
Haupt Melina,
Schuster Anja,
Holzmann Bernhard,
Kessler Horst
Publication year - 2002
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/1439-7633(20020603)3:6<575::aid-cbic575>3.0.co;2-7
Subject(s) - peptidomimetic , integrin , sequence (biology) , chemistry , nuclear magnetic resonance spectroscopy , stereochemistry , computational biology , combinatorial chemistry , biochemistry , biology , peptide , receptor
Anti‐inflammatory drug candidates could result from efforts to reduce the peptidic character of integrin antagonists such as the compound shown in the scheme. Synthesis and NMR spectroscopy structural analysis of peptidomimetics that act as α4β7‐integrin antagonists provided important information about the structural and functional requirements of the Leu‐Asp‐Thr recognition sequence for α4β7 integrins.