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Molecular Insights into Error‐Prone DNA Replication and Error‐Free Lesion Bypass
Author(s) -
Marx Andreas,
Summerer Daniel
Publication year - 2002
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/1439-7633(20020503)3:5<405::aid-cbic405>3.0.co;2-4
Subject(s) - dna polymerase , polymerase , dna replication , dna polymerase ii , genetics , biology , dna clamp , dna , computational biology , fidelity , computer science , polymerase chain reaction , gene , reverse transcriptase , telecommunications
New DNA polymerase structures that differ significantly from known high‐fidelity DNA polymerases provide new insights into how polymerases bypass damaged DNA like 1 . Crystal structures of several Y‐family DNA polymerases have recently been solved (see right‐hand picture) and suggest that more open active sites may be the reason for the error propensity of low‐fidelity polymerases.