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A Novel Cyclodextrin‐Derived Tellurium Compound with Glutathione Peroxidase Activity
Author(s) -
Ren Xiaojun,
Xue Yan,
Liu Junqiu,
Zhang Kun,
Zheng Jian,
Luo Guimin,
Guo Canhui,
Mu Ying,
Shen Jiacong
Publication year - 2002
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/1439-7633(20020402)3:4<356::aid-cbic356>3.0.co;2-o
Subject(s) - cyclodextrin , tellurium , chemistry , peroxidase , glutathione peroxidase , glutathione , combinatorial chemistry , biochemistry , stereochemistry , enzyme , organic chemistry
A novel dicyclodextrinyl ditelluride (2‐TeCD) compound was devised as a functional mimic of the glutathione peroxidase (GPX) enzymes that normally remove hydroperoxides from the cell. The GPX activity of the mimic was found to be 46.7 U μ M −1 , which is 46 times as active as Ebselen, a well‐known GPX mimic. A detailed steady‐state kinetic study was undertaken to probe the reason for the high catalytic efficiency of 2‐TeCD. This high efficiency can be explained based on both the binding of the substrate to the cyclodextrin and the catalytic mechanism of 2‐TeCD, which is different from that of diselenide compounds. 2‐TeCD exhibits good water solubility and is chemically and biologically stable. The biological effect of 2‐TeCD was evaluated by its ability to protect mitochondria from oxidative damage. 2‐TeCD exhibited excellent antioxidant capacity in comparison with Ebselen.