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Synthesis and Characterisation of Acyl Carrier Protein Bound Polyketide Analogues
Author(s) -
Arthur Christopher,
Cox Russell J.,
Crosby John,
Rahman Mujiber M.,
Simpson Thomas J.,
Soulas Florilene,
Spogli Roberto,
Szafranska Anna E.,
Westcott James,
Winfield Christopher J.
Publication year - 2002
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/1439-7633(20020301)3:2/3<253::aid-cbic253>3.0.co;2-7
Subject(s) - polyketide , acyl carrier protein , actinorhodin , polyketide synthase , acylation , chemistry , biosynthesis , stereochemistry , biochemistry , combinatorial chemistry , enzyme , catalysis
β ‐oxoacyl thiolesters of N ‐acetylcysteamine (SNACs, see structure) were synthesised and shown to be substrates for the self‐acylation reaction of the Type II actinorhodin polyketide synthase holo acyl carrier protein (ACP). The preparation of ACPs bearing analogues of polyketide biosynthesis intermediates is described.