Premium
Diels–Alderases
Author(s) -
Pohnert Georg
Publication year - 2001
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/1439-7633(20011203)2:12<873::aid-cbic873>3.0.co;2-a
Subject(s) - catalysis , chemistry , decalin , enzyme catalysis , enzyme , combinatorial chemistry , mechanism (biology) , stereochemistry , organic chemistry , philosophy , epistemology
Nature can do Diels–Alder reactions too! Enzymatic catalysis of this type of reaction is found to play a key role in the formation of secondary metabolites, like the decalin precursor of lovastatin (see scheme). Insight into the detailed mechanism of protein catalysis was obtained by structural investigation of catalytic antibodies with Diels–Alderase activity.