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Discovery of Superior Enzymes by Directed Molecular Evolution
Author(s) -
Brakmann Susanne
Publication year - 2001
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/1439-7633(20011203)2:12<865::aid-cbic865>3.0.co;2-6
Subject(s) - directed evolution , computational biology , chemistry , enzyme , molecular evolution , biochemistry , biology , nanotechnology , materials science , phylogenetics , gene , mutant
The pool of catalysts created by nature is unmatched—under natural conditions. Because the demands of modern synthesis and the possible commercial application of enzymes were not taken into account during the natural evolution of these biocatalysts, scientists developed a repertoire of strategies, called “directed evolution”, for improving enzyme function and, meanwhile, vie with nature for the best enzymes ever seen.